132 articles - From Friday Aug 29 2025 to Friday Sep 05 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Aliment Pharmacol Ther |
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| Am J Gastroenterol |
ACG Clinical Guideline: Perioperative Risk Assessment and Management in Patients With Cirrhosis. Furthermore, it addresses procedure-specific considerations, including the role of bariatric and cardiac surgeries in cirrhotic patients. Through evidence-based recommendations and expert insights, this guideline aims to enhance surgical outcomes and inform clinical decision-making in a growing population of patients with cirrhosis undergoing surgery. |
| Clin Gastroenterol Hepatol |
International Magnetic Resonance Imaging Consensus for use in Luminal Crohn's Disease Trials and Clinical Practice. A consensus expert panel has developed standardized definitions of MRE response, remission, as well as the optimal timing for response assessment in patients with luminal Crohn's disease. Further research is needed to clarify the method for measuring transmural healing. |
| Endoscopy |
Adherence to Clinical Practice Guidelines for Management of Epithelial Precancerous Conditions and Lesions in the Stomach in Europe. Adherence to MAPS guidelines improved in most centers. However, gaps in virtual chromoendoscopy, targeted biopsies, and endoscopic/histopathological scoring remain, potentially affecting surveillance recommendations. This underscores the need for a more tailored approach to enhance implementation. |
| Gut |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Meta-Analysis: Comparison of Living Versus Deceased Liver Transplantation for Primary Sclerosing Cholangitis. In PSC, LDLT seems to be associated with higher post-LT survival, compared with DDLT. This could be explained by earlier referral to LT with lower liver disease burden and better performance status; better graft quality; and shorter cold ischaemia time. PSC patients requiring LT should be encouraged to consider LDLT. |
| Endosc Int Open |
Single-use versus reusable endoscopes in gastroenterology: Systematic review of full and partial economic evaluations. Future economic evaluations of single-use vs reusable endoscopes require more robust comparative evidence and should include costs and consequences beyond health, especially environmental impact. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Burden of Invasive Fungal Diseases in Patients With Alcohol-Related Hepatitis and Organ Failure. IFDs affected 1 in 50 CAH patients and carried a disproportionate mortality risk, compared with BP. These findings support the implementation of targeted screening and early antifungal strategies in CAH management, as for BP. |
Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis. In patients with AIH, clinical features of CSPH reflect the risk of future hepatic decompensation and mortality. Hence, regular screening for CSPH in AIH patients seems warranted to ensure timely initiation of adequate CSPH-directed treatment. |
Research Communication: Serum Metabolomic Signatures Predict Tumour Recurrence After Resection or Ablation in Patients With Early-Stage Hepatocellular Carcinoma. In multivariable analysis, the 6-metabolite signature was associated with early recurrence (aHR 2.8, 95% CI 1.1-7.5), and the 13-metabolite signature was associated with overall recurrence (aHR 2.5, 95% CI 1.1-6.0). These data support the potential role of serum metabolites in post-treatment risk stratification for HCC recurrence. |
| Am J Gastroenterol |
Gastrointestinal and Hepatobiliary Safety of Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes. In this large real-world cohort study, GLP-1 RA therapy was not associated with increased risk of most serious GI or hepatobiliary outcomes compared to other oral diabetes medications. These findings support the overall GI and hepatobiliary safety of GLP-1 RAs in patients with type 2 diabetes, while underscoring the need for vigilance regarding gastroparesis and intussusception in susceptible individuals. Longer-term studies are warranted to fully evaluate cancer risk. |
Protective association of healthy lifestyle behaviours with incident functional constipation: A population-based prospective cohort study. Adopting a higher number of healthy lifestyle behaviours is significantly associated with a reduced incidence of FC in the middle-aged and elderly population, indicating their potential to be a primary prevention strategy. Future research should explore underlying mechanisms and replicate our investigation across diverse populations. |
Real-Life Clinical Validation of AI-Assisted Detection and Differentiation of Pleomorphic Lesions in Capsule Endoscopy. This was the first multicentric study proving AI-assisted CE reading superiority compared to conventional reading. The inclusion of videos from multiple devices addresses the interoperability challenge, whereas including patients from 4 countries and two different continents assures a diverse demographic context. AI achieved gastroenterologist-level identification of small-bowel lesions, surpassing conventional reading methods in both lesion detection and characterization. |
Risk of venous thromboembolism following colorectal cancer surgery in patients with and without inflammatory bowel disease. Patients with IBD are at elevated risk of VTE following CRC surgery compared to those without IBD. The strongest associations were observed in those who had received IBD treatment before surgery and in those with active disease, particularly patients with UC. These findings emphasize the need for increased VTE awareness and optimizing disease control in high-risk IBD patients. |
Screening for Barrett's Esophagus and Esophageal Adenocarcinoma: Approaches and Outcomes. While direct evidence linking screening to reduced EAC mortality is lacking, trials highlight promising outcomes in early detection of precancerous and cancerous lesions. Future directions, challenges, and recommendations for optimizing BE screening are discussed. |
Sub-cutaneous infliximab for perianal Crohn's disease: the BioLap-Rem multicentre study from the GETAID. SC IFX was effective and safe for the treatment of active pCD and for maintaining remission after switching in this large multicentre cohort, thus supporting its use in routine practice in this indication. |
| Clin Gastroenterol Hepatol |
Defining non-invasive criteria for indicating drug therapy in metabolic-associated steatotic liver disease in clinical practice. The diagnostic performance and reliability of the proposed non-invasive criteria for initiating resmetirom treatment were suboptimal.About the half of patients with indication would not receive treatment under these criteria.A new strategy, using FIB-4, the presence of diabetes and overweight, and liver stiffness improved the identification of MASLD patients with fibrosis stage 2-3. |
Glucagon-like peptide-1 receptor agonists are associated with a lower risk of peptic ulcer disease: a nationwide cohort study. In this nationwide cohort study of T2DM patients, GLP-1 RA use was associated with 44% lower odds of PUD. In our propensity-score matched sub-group, switching to GLP-1 RA as second-line therapy was associated with a 56% lower hazard of PUD vs insulin. These findings indicate an association between GLP-1 RA use and reduced risk of PUD. |
Reliability and Responsiveness of Endoscopic Indices for Assessing Crohn's Disease Postoperative Recurrence in the PREVENT trial. Existing endoscopic indices are reliable and responsive for assessing postoperative CD activity in the neoterminal ileum, although are suboptimal for evaluation in the anastomosis or distal colonic segment. |
| Endosc Int Open |
Capnography monitoring reduces incidence of hypoxia in older patients undergoing gastrointestinal endoscopy under propofol sedation. Additional capnography monitoring during gastrointestinal endoscopy for older patients who were sedated with propofol reduces incidence of hypoxia. |
Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis. Direct visualization ERAT demonstrated high feasibility and effectiveness as a diagnostic and therapeutic modality for acute uncomplicated appendicitis, offering a promising alternative to conventional approaches. |
Efficacy of endoscopic intermuscular dissection vs. endoscopic submucosal dissection in treating rectal neuroendocrine tumors < 10 mm. Endoscopic intermuscular dissection offers a better option for preventing positive basal margins and demonstrates good safety and feasibility. |
Efficacy of remimazolam with fentanyl vs midazolam with fentanyl for sedation in screening colonoscopy: Randomized controlled study. This study shows clear superiority of the combination of remimazolam with fentanyl over midazolam with fentanyl for conscious sedation in screening colonoscopy, obtaining shorter procedure time, less postoperative need for observation, lower patient pain scores, and higher patient satisfaction. |
Efficacy of serial pancreatic juice aspiration cytological examination for focal pancreatic duct stenosis: Multicenter, retrospective, cohort study. SPACE was a valuable method for obtaining pathological specimens of focal pancreatic duct stenosis. It yielded improved diagnostic sensitivity and accuracy compared with initial cytology alone. |
Endoscopic papillectomy of major papilla lesions: Single tertiary care center experience. R0 resection was associated with reduced risk of recurrence whereas delayed bleeding after EP is associated with an increased risk of developing PEP. EP is safe and effective for removing ampullary lesions irrespective of lesion type. |
Evaluation of the clip anchorage technique using mucosal elevation and incision in prevention of esophageal stent migration. The new esophageal stent fixation technique appears to be simple, inexpensive, feasible, and safe. Although there is no impact on overall migration, there does seem to be a reduction in early migration. |
Feasibility and safety of endoscopic resection for duodenal gastrointestinal stromal tumors. ESD and EFTR are safe, minimally invasive treatments for duodenal GISTs. Moreover, the EFTR technique may have advantages of completely resecting lesions originating from the deep muscularis propria layer, particularly lesions with extraluminal growth. |
GastroGPT: Development and controlled testing of a proof-of-concept customized clinical language model. This study pioneered development and comparison of a specialty-specific, clinically-oriented AI model to general-purpose LLMs. GastroGPT demonstrated superior utility overall and on key gastroenterology tasks, highlighting the potential for tailored, task-focused AI models in medicine. |
Histology of colonic submucosal lesions reveals a high proportion of benign lesions that do not require R0 en bloc endoscopic resection. Most colonic submucosal lesions are non-malignant and do not warrant advanced endoscopic resection. A new therapeutic approach could be first-line use of a low-risk, low-cost histological diagnostic technique followed in a second phase by a more advanced technique in the event of a malignant histological result. Further studies are needed to evaluate this step-up strategy. |
Hyperbaric oxygen and steroids for preventing stricture after large esophageal endoscopic submucosal dissection. HBOT-assisted steroid therapy might be a safe and effective way to prevent postoperative strictures after ESD for large and long-segment esophageal mucosal lesions. |
Optimal endoscopic resection method based on vertical margin distance for small rectal neuroendocrine tumors: Propensity score-matched study. EMR-L outperforms ESD for small rectal NETs by achieving higher R0 and better vertical margins in shorter times, while minimizing risk of perforation. |
Outcomes of endoscopic submucosal dissection for treatment of superficial anal squamous cell carcinoma: Multicenter international experience. ESD is a feasible and effective treatment for superficial ASCC. Adverse events were successfully managed with medical or endoscopic therapy. ESD should be considered as first-line resection technique to prevent recurrence while preserving anal sphincter function. |
Prospective study on outcomes of endotherapy for pancreatic divisum in patients of recurrent acute pancreatitis. Minor papilla endotherapy for RAP significantly improved VAS scores at 12 months among 69.1% of patients with acceptable AEs. Early CP was seen in 11.7% of patients. (Unique identifier CTRI/2019/05/019332). |
Reducing applied force in colonoscopy using a novel soft robotic colonoscope: Head-to-head study. This study demonstrated an improvement in force with the novel soft robot compared with a standard colonoscope. This suggests the possibility of more comfortable colonoscopy for patients. Currently time taken is longer with the novel robot, which is attributable to the learning curve and improves in subsequent passes. Further work will be undertaken in a complete colon model with aspirations to reach in-vivo experiments. |
Single-center, prospective study evaluating safety and efficacy of a new endoscopic hemostat system in non-variceal upper gastrointestinal bleeding. Resolv Endoscopic Hemostat System is a safe and effective device for achieving immediate hemostasis in patients with non-variceal upper gastrointestinal bleeding. Future studies are required to examine its widespread adoption and applicability. |
| Endoscopy |
Carbon footprint assessment and sensitivity analysis of diagnostic colonoscopy. This analysis and multifactorial colonoscopy procedure assessment has confirmed patient and staff transportation are the main carbon footprint contributors. A more sustainable and smarter mobility can considerably lower the environmental impact. |
Clinical implications of computer-aided real-time size estimation of colorectal polyps during colonoscopy. The AI tool assigned 90.8% of patients to correct surveillance intervals and achieved a MAE of 1.13 mm and RMSE of 1.40 mm for polyps ≤10 mm. CONCLUSIONS The AI model performs similarly to expert endoscopist in clinically relevant size-related endpoints, potentially improving the accuracy and efficiency of colorectal cancer screening. |
Colon capsule endoscopy compared to conventional colonoscopy in patients with colonic diverticulitis: a randomised controlled superiority trial. CCE is a safe procedure for follow-up in patients after an episode with CD and is preferred by a majority of the patients compared to colonoscopy, but those receiving both modalities differed. |
Colorectal mucosal exposure area assessment based on artificial intelligence: a multi-center, prospective, observational study. The CCMEA qualified group, based on a CCMEA threshold of 2000, shows higher ADR than the unqualified group, indicating CCMEA can be a promising colonoscopy quality indicator. |
Comparing low-volume vs. intermediate volume bowel preparation and its impact on work and tolerability: An open-label, non-inferiority, randomized controlled trial. Bowel preparation with 1L PEG+Asc is non-inferior to 2L PEG+Asc and has a higher willingness-to-repeat. Tolerability is fundamental for effective cleansing and reducing colonoscopy barriers. |
Pilot study on using a photometric capsule to stratify patients with suspected nonvariceal upper gastrointestinal bleeding into emergency versus elective endoscopy. No technical, PCE-related, or bleeding-related complications occurred during the follow-up period (30 days). PCE was a quick and easy-to-use method with a high negative predictive value for suspected NVUGIH and could be used to identify patients in whom emergency endoscopy can be avoided. |
| Gastrointest Endosc |
Utility of Random Neo-Squamous and Cardia Biopsies During Surveillance After Dysplastic Barrett's Eradication: A Prospective Single- Center Study. Targeted biopsies of the NE and gastric cardia are important in detecting early BE recurrence. Additional random NE and cardia biopsies provide no added benefit in dysplasia detection but incur unnecessary time and cost expenditures. We recommend targeted biopsies as the primary surveillance strategy post-CEIM and eliminating random biopsies in expert centers. |
| Gut |
<i>Bacteroides intestinalis</i> mediates the sensitivity to irinotecan toxicity via tryptophan catabolites. Our study uncovers the mechanism of endogenous bacterial metabolite in shaping the individual susceptibility to irinotecan toxicity and suggests IAA as a potential predictive biomarker. |
Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome. iCCA is characterised by a profoundly immunosuppressive TME that impairs B-cell function through soluble factors and cellular interactions. Our findings identify B cells as biomarkers and therapeutic targets, supporting strategies to restore B-cell function and promote mature TLS to enhance immunotherapy responsiveness in iCCA. |
Outcome of a FODMAP restriction diet with subsequent blinded reintroduction in functional dyspepsia/postprandial distress syndrome. A LFD significantly improved PDS symptoms, but this was not associated with altered mucosal integrity. Powder reintroduction identified a large variety in individual FODMAPs and glucose as triggers. |
| Hepatology |
Early on-treatment LSM reliably predicts liver-related events in CHB patients with significant fibrosis and cirrhosis. On-treatment LSM measured 1-3 years after antiviral therapy offers superior predictive accuracy for LREs compared with baseline or LSM changes, with LSM <10 kPa indicating a significantly lower risk, likely due to improved lobular architecture. |
Integrative hepatology: Enhancing overall health to manage liver disease. Implementation faces challenges, including evidence gaps, limited training, time constraints, reimbursement barriers, and inequitable access, but opportunities exist through education, interdisciplinary collaboration, group medical visits, and digital health delivery. By expanding the scope of liver care to include whole-person health, Integrative Hepatology seeks not to replace established therapies but to augment their impact-supporting patients in achieving optimal health across the disease spectrum. |
| J Hepatol |
Alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced hepatocellular carcinogenesis. The data demonstrated that alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced HCC (HBV-HCC). LPLA2 is a potential therapeutic target and a probable marker of poor prognosis for HCC patients. Impact and implications Chronic alcohol consumption promotes HBV-induced hepatocellular carcinogenesis (HBV-HCC). ATF4/LPLA2-mediated BMP metabolism promotes alcohol-enhanced HBV-HCC via MAPK/ERK signaling pathway. Targeting LPLA2 or BMP metabolism markedly inhibited HBV-HCC progression. This preclinical study provides a theoretical basis to investigate novel strategies for HCC therapy. |
Engineered monoclonal antibody tobevibart enhances HBsAg capture by Fc receptor-positive cells and activates HBV-specific T cells. We demonstrate that tobevibart combines the advantages of potent neutralization of HBV and HDV with FcγR-mediated reduction of HBsAg and enhancement of T cell responses. Tobevibart is under clinical investigation alone or in combination with other agents to treat patients with chronic hepatitis delta and to induce functional cure of patients with CHB. Impact and implications () Chronic infection with hepatitis B virus (HBV) or co-infection with hepatitis delta virus (HDV) can cause severe liver disease and cancer. We previously showed that the monoclonal antibody tobevibart potently neutralizes HBV and HDV. Here we demonstrate that the engineered Fc region of tobevibart effectively interacted with several immune cell types, potentially facilitating the rapid removal of damaging viral proteins from circulation and activating T cell responses that may control HBV infection long term. Clinical trial VIR-3434-1002, phase 1, ClinicalTrials.gov identifier NCT04423393. |
Healthy eating and physical activity significantly lower sex-specific alcohol-attributable liver mortality in the United States. Healthy eating and increased levels of PA significantly lower the risk of alcohol-attributable liver-related mortality in the US population. Impact and implications This study found that any amount of alcohol intake and binge drinking were associated with an increased risk of liver-related mortality. Adherence to healthy dietary patterns and increased physical activity lower the risk of liver mortality across al drinking patterns, including heavy and binge drinking. Liver survival benefits from both physical activity and diet quality are greater in women than men. A diet rich in vegetables, fruits, grains, seafood, plant-based proteins, and unsaturated fatty acids, combined with a reduced intake of empty calories from solid fats, alcohol, and added sugars, is associated with a lower risk of liver-related mortality. Economically disadvantaged populations are exposed to high-risk alcohol use, unhealthy diet, and physical inactivity, and therefore increased liver mortality. |
Risk of alcohol-related liver disease and cause-specific mortality in individuals seeking treatment for alcohol use disorder. This study showed the substantial burden of alcohol-related disease and mortality in individuals seeking treatment for AUD. Specifically, the risk of ALD was 7% after 10 years, 13% in those with type 2 diabetes. Impact and implications Knowledge of the absolute risk of alcohol-related liver disease (ALD) and cause-specific death among individuals in treatment for alcohol use disorder is crucial to make decisions on screening for ALD. The study highlights the need for improved care of individuals in treatment for alcohol-use disorder to prevent morbidity and mortality due to ALD, other alcohol-related causes, but also cancer and cardiovascular disease. The higher risk of ALD in those with type 2 diabetes suggests that clinicians should be specifically aware of alcohol consumption and liver disease in their patients with type 2 diabetes. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
HIGH-RESOLUTION MANOMETRY IN TREATED ACHALASIA: SCOPING REVIEW AND NOVEL NOMENCLATURE. This scoping review with expert recommendations provides guidance for HRM interpretation in treated achalasia and introduces novel descriptive terms to describe pathophysiology following achalasia treatment. Conventional CC should not be used in treated achalasia description. |
| Endosc Int Open |
| Gastroenterology |
| J Hepatol |
Cellular Senescence in Liver Diseases: From Molecular Drivers to Therapeutic Targeting. Recent advances, such as multi-omics profiling, multi-marker gene signatures, and targeted modalities including PROTACs and CAR-T cell therapies, offer new opportunities for precision interventions. This review synthesizes emerging insights into the molecular mechanisms of liver senescence, evaluates the current landscape of senotherapies, and outlines key challenges and future directions for safely and effectively targeting senescence in chronic liver disease. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Gastrointest Endosc |
| Gut |
| J Hepatol |